Aspergillus arthritis and organ transplantation
نویسندگان
چکیده
We report a case of a kidney and pancreas transplanted patient, hospitalized for septic hip arthritis. The whole diagnostic work-up including synovial and bone biopsies remained negative. After inefficient empirical anti-bacterial antibiotic treatment, femoral head resection was performed and tissue analysis revealed Aspergillus fumigatus hyphae. Treatment with voriconazole along with hip replacement led to complete recovery. However, drug interaction between immunosuppressive and anti-fungal drugs was complicated by cellular acute graft rejection. Aspergillus fumigatus arthritis is an uncommon and serious infection that should be evoked especially in the case of resistance to anti-microbial antibiotics and/or an atypical clinical picture.
منابع مشابه
Aspergillus fumigatus spondylodiskitis in renal transplant patient: voriconazole experience.
The incidence of invasive aspergillosis has increased after solid organ transplant. However, aspergillus osteomyelitis in vertebrae is rare. We report a case of aspergillus spondylodiskitis after pulmonary aspergillosis in a renal transplant recipient. He was treated by antifungal therapy and surgical intervention. The transplantist should be alert for a diagnosis of aspergillus spondylodiskiti...
متن کاملFalse-positive Aspergillus galactomannan assay in solid organ transplant recipients with histoplasmosis.
Post-transplantation histoplasmosis may be acquired via inhalation, may result from endogenous reactivation, or may be derived from the allograft. The Histoplasma and Aspergillus enzyme-linked immunoassays are increasingly being relied upon for rapid diagnosis of fungal infections, especially in immunocompromised patients. We describe 4 cases of solid organ transplant recipients who had histopl...
متن کاملDetection of Aspergillus Species by Polymerase Chain Reaction
Aspergillus species have recently caused increasing numbers of life-threatening acute invasive infections in immunocompromised patients (Kontoyiannis et al., 2002). The steadily increasing incidence of invasive aspergillosis over the last few decades is ascribable to the increasing number of patients undergoing chemotherapy, bone marrow or solid organ transplantation and intensive corticosteroi...
متن کاملCytomegalovirus infection is a risk factor for invasive aspergillosis in lung transplant recipients.
Invasive aspergillosis (IA) remains a major cause of morbidity and mortality following solid organ transplantation. To assess the incidence of IA following lung transplantation and to identify risk factors for its occurrence, we performed a case-control study involving 101 patients undergoing lung transplantation at our institution from 1990 to 1995 and reviewed the findings. Fourteen patients ...
متن کاملAspergillus 'fungus ball' within a cadaveric renal transplant graft.
Filamentous fungal infections are associated with a high morbidity and mortality in solid organ transplants. Species of the Aspergillus family account for the majority of these infections, and Aspergillus fumigatus, in particular, may be regarded as the most important airborne saprophytic fungus [1,2]. There are numerous conidia of this fungus inhaled constantly by humans, which are normally el...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2012